Acromegaly and the thyroid gland

Table 1 Studies with control group included in meta-analysis – the table taken from the study by Wolinski et al. [4], modified. Asterisk (*) - persons with non-functioning or Prl secreting adenomas.

Studies with control group	Acromegalic patients	Cases of thyroid carcinoma in group of acromegalic patients	Control group	Cases of thyroid carcinoma in control group	Odds ratio
dos Santos et al., Pituitary 2013;16:109-114	124	9 (7.25%)	263 (not specified)	2 (0.76%)	9.5 (2.2-48.0)
Herrmann et al., Clin Endocrinol Diabet. 2004;112:225–230; retrospective	73	4 (5.5%)	199 (healthy volunteers)	0	25.8 (1.4-486.0)
Gasperi et al., J Endocrinol Invest. 2002;25:240-245	258	3 (1.16%)	150*	1 (0.66%)	1.7 (0.2-16.9)
Popovic et al. Clin Endocrinol (Oxf) 1998;49: 441–445; retrospective	220	3 (1.36%)	248*	0	8.0 (0.4-155.7)
Barzilay et al., Arch Intern Med. 1991;151:1629–1632; retrospective	87	2 (2.3%)	198*	0	11.6 (0.6-244.4)
Total					7.9 (2.8-22.0)

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