Antithyroid drugs and birth defects

Table 3 Observational studies on the use of both Methimazole and Propylthiouracil in early pregnancy and outcome of birth defects

Author	Year	Country	Data source	Exposed (n)^a	Outcome in non-exposed (%)	Outcome in exposed (%)	Association^b
Korelitz et al. [20]	2013	United States	Health insurance database	126	5.9	11.1	Yes
Andersen et al. [15]	2013	Denmark	Nationwide prescription register	159	5.7	10.1	Yes
Lo et al. [21]	2015	United States	Health insurance database	49	4.4	4.1	No
Andersen et al. [18]	2017	Sweden	Nationwide prescription register	66	8.0	6.1	No
Seo et al. [14]	2018	Korea	Health insurance database	1840	5.9	8.0	Yes
Andersen et al. [16]	2019	Denmark	Nationwide prescription register	255	6.7	7.8	No

^aNumber of children exposed to both Methimazole and Propylthiouracil in the early pregnancy, see text for details
^bIndicates whether an association between exposure to both Methimazole and Propylthiouracil and birth defects was observed, see text for details

ISSN: 1756-6614